Thermo Fisher Scientific GCH1 Monoclonal Antibody (4A12)
Human GCH1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot, IHC, ELISA, IP 등에 사용 가능. 액상 형태이며 PBS buffer에 보존, -20°C 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific GCH1 Monoclonal Antibody (4A12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 3 µg/mL |
| ELISA | 0.3 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A12 |
| Immunogen | GCH1 (NP_000152, 84–172 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ENPQRQGLLK TPWRAASAMQ FFTKGYQETI SDVLNDAIFD EDHDEMVIVK DIDMFSMCEH HLVPFVGKVH IGYLPNKQVL GLSKLARIV
Target Information
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate.
BH4 is an essential cofactor required by aromatic amino acid hydroxylases and nitric oxide synthases.
Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia.
Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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