Thermo Fisher Scientific GCG Monoclonal Antibody (2D3-2B11)
Glucagon 단백질을 인식하는 Thermo Fisher Scientific의 Mouse monoclonal antibody (Clone 2D3-2B11). Western blot과 ELISA에 적합하며, 높은 특이성과 재현성을 제공. 연구용으로 사용되며, 인간 시료에 반응.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D3-2B11 |
| Immunogen | GCG (AAH05278, 1–180 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK
Target Information
Glucagon is a 29-residue polypeptide hormone (MW 3482) produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), found in the intestinal mucosa, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 residues at the C-terminus.
Biological activities of pancreatic glucagon include:
- Glycogenolysis
- Lipolysis
- Gluconeogenesis
- Ketogenesis
These effects are antagonistic to insulin action, resulting in increased blood glucose levels.
Immunocytochemical studies show pancreatic glucagon localized in A (alpha) cells, comprising 15–20% of islet cells, mainly at the periphery of pancreatic islets. Pathological conditions related to glucagon typically involve tumors (glucagonomas), as no glucagon-cell deficiency or hyperplasia states are known.
Glucagon-specific antibodies are useful as:
- Cell and tumor markers in immunohistochemistry
- Analytical tools for hormone quantification
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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