Thermo Fisher Scientific Phospho-Cullin 4B (Thr48) Polyclonal Antibody
CUL4B 단백질의 Thr48 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며 인간, 생쥐, 랫드 반응성. 고순도 정제, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CUL4B (Accession Q13620), corresponding to amino acid residues around phosphorylated Thr48 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816786 |
Product Specific Information
Antibody detects endogenous levels of CUL4B only when phosphorylated at Thr48.
Target Information
CUL4B is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes that mediate ubiquitination and proteasomal degradation of target proteins. It acts as a scaffold protein, positioning substrates and ubiquitin-conjugating enzymes for catalysis.
CUL4B participates in polyubiquitination of CDT1, histones H2A, H3, and H4 following radiation-induced DNA damage, and is targeted to UV-damaged chromatin by DDB2, playing a role in DNA repair and replication.
It is required for ubiquitination of cyclin E, supporting normal G1 cell cycle progression, and regulates the mTOR pathway controlling cell growth, size, and metabolism. This regulation depends on 26S proteasome function and interaction between CUL4B and MLST8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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