Thermo Fisher Scientific MMP2/Collagenase Type IV A (Tumor Metastasis Marker) Monoclonal Antibody (4D3)
인간 MMP2 단백질을 인식하는 Mouse IgG1 단클론 항체로 종양 전이 및 조직 재형성 연구에 적합함. IHC(PFA 고정) 실험에 사용 가능하며, 200 µg/mL 농도의 액상 형태로 제공. Protein A/G 정제, 4°C 보관.
- 카탈로그번호
- 4313-MSM4-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MMP2/Collagenase Type IV A (Tumor Metastasis Marker) Monoclonal Antibody (4D3)
Applications
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D3 |
| Immunogen | Recombinant human MMP2 protein fragment (aa557–569) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a common activation mechanism, a conserved amino acid sequence in the metal-binding active site region, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs).
MMPs and TIMPs regulate angiogenesis and tissue remodeling. MMP2 is synthesized as a 631 amino acid proenzyme that becomes active upon cleavage of the first 80 amino acids. It contains propeptide, catalytic, and hemopexin domains.
MMP2 mutations have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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