Thermo Fisher Scientific CYP1A2 Monoclonal Antibody (UMAB105), UltraMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CYP1A2 gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
The encoded protein localizes to the endoplasmic reticulum and its expression is induced by polycyclic aromatic hydrocarbons (PAHs), such as those found in cigarette smoke.
Although the enzyme’s endogenous substrate is unknown, it can metabolize certain PAHs to carcinogenic intermediates. Other known substrates include caffeine, aflatoxin B1, and acetaminophen.
The transcript of this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.