Thermo Fisher Scientific MEKK3 Polyclonal Antibody
MEKK3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 적합. 인간 및 마우스 반응성. 고순도 친화 크로마토그래피 정제 제품으로 연구용에 최적화.
- 카탈로그번호
- PA5101246
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: [References not provided]
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K3 (Accession Q99759), corresponding to amino acid residues V76–N126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850687 |
Product Specific Information
This antibody detects endogenous levels of total MAP3K3.
Target Information
MAP3K3 (MEKK3) directly regulates MAPK8 and ERK pathways by phosphorylating multiple MAP2Ks. Northern blot analysis shows a 4.6-kb transcript expressed ubiquitously. It regulates SAPK and ERK pathways by activating SEK and MEK1/2, but not the p38 pathway. In cotransfection assays, it enhances transcription from an NF-κB–dependent reporter gene, consistent with its role in the SAPK pathway. Alternatively spliced variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 제품 관련 이미지 파일명: PA5-101246_MEKK3_Q99759-1_Rabbit.svg, PA5-101246_MEKK3_Q99759-1_Rabbit_PDP.jpeg)
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