Thermo Fisher Scientific TANK Polyclonal Antibody
TANK 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 2–8°C 보관 권장.
- 카탈로그번호
- PA520270
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the carboxy terminus of human TANK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at –20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152622 |
Product Specific Information
- Suggested positive control: Daudi cell lysate
- PA5-20270 can be used with blocking peptide PEP-0385
Target Information
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Ligand binding by surface receptors in the TNF receptor and Toll/interleukin-1 receptor families leads to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation occurs through association with kinases IKK-iota and TBK1. These proteins can form a complex with NEMO, which regulates Ikappa-B complex activity. This suggests that TBK1 and IKK-iota may also modulate other functions such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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