Thermo Fisher Scientific TANK Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: Daudi cell lysate
• PA5-20270 can be used with blocking peptide PEP-0385

Target Information

TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Ligand binding by surface receptors in the TNF receptor and Toll/interleukin-1 receptor families leads to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation occurs through association with kinases IKK-iota and TBK1. These proteins can form a complex with NEMO, which regulates Ikappa-B complex activity. This suggests that TBK1 and IKK-iota may also modulate other functions such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.