Thermo Fisher Scientific GCK Polyclonal Antibody, MaxPab
Thermo Fisher Scientific의 GCK Polyclonal Antibody는 인간, 생쥐, 랫트에 반응하는 rabbit IgG 형의 비결합 항체입니다. Western blot 및 ICC/IF에 사용 가능하며, PBS buffer에 보존되어 연구용으로 적합합니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | GCK (AAH01890.1, 1–465 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MLDDRARMEA AKKEKVEQIL AEFQLQEEDL KKVMRRMQKE MDRGLRLETH EEASVKMLPT YVRSTPEGSE VGDFLSLDLG GTNFRVMLVK VGEGEEGQWS VKTKHQMYSI PEDAMTGTAE MLFDYISECI SDFLDKHQMK HKKLPLGFTF SFPVRHEDID KGILLNWTKG FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDHQC EVGMIVGTGC NACYMEEMQN VELVEGDEGR MCVNTEWGAF GDSGELDEFL LEYDRLVDES SANPGQQLYE KLIGGKYMGE LVRLVLLRLV DENLLFHGEA SEQLRTRGAF ETRFVSQVES DTGDRKQIYN ILSTLGLRPS TTDCDIVRRA CESVSTRAAH MCSAGLAGVI NRMRESRSED VMRITVGVDG SVYKLHPSFK ERFHASVRRL TPSCEITFIE SEEGSGRGAA LVSAVACKKA CMLGQ
Target Information
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, committing glucose to the glycolytic pathway.
Alternative splicing of this gene results in three tissue-specific forms of glucokinase: one in pancreatic islet beta cells and two in liver.
The protein localizes to the outer membrane of mitochondria and, unlike other hexokinases, is not inhibited by glucose-6-phosphate.
Mutations in this gene are associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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