Thermo Fisher Scientific UNC93B1 Polyclonal Antibody
UNC93B1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성 확인됨. 항원 친화 크로마토그래피로 정제된 액상형 항체로 1 mg/mL 농도. 심장 조직 lysate를 양성 대조로 추천.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the amino terminus of human Unc93b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152747 |
Product Specific Information
- Suggested positive control: human heart tissue lysate
- PA5-20510 can be used with blocking peptide PEP-0630
Target Information
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was identified by a forward genetic screen using N-ethyl-N-nitrosourea. A histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7, and 9 signaling.
Unlike Unc93a, whose function is unknown, Unc93b specifically interacts with TLR3, 7, and 9. The mutation abolishes this interaction, making mice highly susceptible to viral infection, indicating Unc93b’s role in innate immunity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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