Thermo Fisher Scientific LGI4 Polyclonal Antibody
Thermo Fisher Scientific의 LGI4 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가지며 Western blot에 최적화된 항체입니다. 항원 친화 크로마토그래피로 정제된 액상 형태로, 신경 발달 및 LGI4 관련 연구에 적합합니다. 장기 보관은 -20°C에서 가능합니다.
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Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the center of human LGI4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152141 |
Product Specific Information
- Suggested positive control: Rat brain tissue lysate
- PA5-20515 can be used with blocking peptide PEP-0635
Target Information
The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family, in which LGI1 is the exemplar. The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs) similar to transmembrane signaling molecules and receptors.
LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), characterized by focal seizures with auditory symptoms.
Despite high homology with LGI1, mutations in LGI4 have not been associated with ADTLE. The LGI4 gene is located in a region linked to benign familial infantile convulsions, and a GC-to-AT polymorphism correlates with childhood absence epilepsy.
Decreasing LGI4 expression in cultured cells inhibits myelination, indicating its role in neural development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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