Thermo Fisher Scientific LGI4 Polyclonal Antibody

Applications

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

• Suggested positive control: Rat brain tissue lysate
• PA5-20515 can be used with blocking peptide PEP-0635

Target Information

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family, in which LGI1 is the exemplar. The LGI family consists of four highly related proteins containing leucine-rich repeats (LRRs) similar to transmembrane signaling molecules and receptors.
LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), characterized by focal seizures with auditory symptoms.
Despite high homology with LGI1, mutations in LGI4 have not been associated with ADTLE. The LGI4 gene is located in a region linked to benign familial infantile convulsions, and a GC-to-AT polymorphism correlates with childhood absence epilepsy.
Decreasing LGI4 expression in cultured cells inhibits myelination, indicating its role in neural development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.