Thermo Fisher Scientific OX40/CD134/TNFRSF4 (Immuno-Oncology Target) Monoclonal Antibody (OX40, 3427)
OX40/CD134 단일클론 항체로 인간 및 침팬지 반응성을 가지며, 면역조직화학 및 ELISA에 적합. T세포 활성화 및 생존을 촉진하는 OX40 표적 연구용 항체. 단백질 A/G로 정제된 액상 형태, 보존제 무첨가, -20°C 이하 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chimpanzee, Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX40, 3427 |
| Immunogen | Recombinant fragment of human OX40 (CD134) protein (aa 59–205) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody tested in direct ELISA.
- For Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
OX40 (CD134) is a surface receptor expressed on activated T cells, playing a key role in immune regulation. Activation of OX40 enhances T cell proliferation and survival, strengthening immune responses against cancer and infections.
OX40 agonists have shown promise in immuno-oncology research, potentially improving outcomes in combination with chemotherapy or checkpoint inhibitors.
They may also have therapeutic relevance in autoimmune and allergic conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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