Thermo Fisher Scientific SFPQ Monoclonal Antibody (B92)
SFPQ 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. 인간 및 마우스 시료에 반응하며, Protein A로 정제된 액상 형태입니다. Alzheimer’s disease 관련 연구에 유용한 핵심 표적 항체입니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Radioimmune Assays (RIA) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B92 |
| Immunogen | Lysate of mouse bone marrow-derived stromal cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2186931 |
Product Specific Information
- Recommended positive control: HeLa cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
SFPQ (also known as PSF) encodes a nuclear factor involved in RNA splicing and gene expression regulation.
It likely forms a heteromer with NONO and participates in DNA pairing and repair processes.
Recent studies have identified SFPQ as a downstream target of tau, showing nuclear depletion and cytoplasmic accumulation in neurons and astrocytes of Alzheimer’s disease brains.
Reduced SFPQ levels may correlate with tau pathology, suggesting its role in neurodegenerative diseases including AD.
SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa molecules depending on cell type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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