Thermo Fisher Scientific IL-22 Polyclonal Antibody
IL-22 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 최적화되어 있으며 인간 및 마우스 시료에서 반응. 항원 친화 크로마토그래피로 정제된 액상 형태, 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific IL-22 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:5,000–1:20,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–97 of IL-22 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552293 |
Product Specific Information
- Recommended positive controls: mouse spleen
- Predicted reactivity: Mouse (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN–IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons.
IL-22 is mainly produced by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and structurally related to IL10.
It acts via a heterodimeric receptor complex consisting of IL-22R1 and IL-10R2, activating JAK-STAT signaling.
IL-22 targets nonimmune cells such as skin, digestive, respiratory cells, hepatocytes, and keratinocytes, and functions as an effector cytokine of Th17 cells.
It induces antimicrobial proteins, acute phase reactants, and promotes wound healing. IL-22 is upregulated during chronic inflammation and mediates IL-23-induced dermal inflammation through STAT3 activation.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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