Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Recombinant Mouse Monoclonal Antibody (rC66, 1009)
인체 CEA/CD66e 항원을 인식하는 Thermo Fisher Scientific의 재조합 마우스 단클론 항체입니다. HEK293 세포에서 발현되었으며, IHC(P) 적용에 최적화되어 있습니다. 단백질 A/G로 정제된 액상 항체로, 보존제 무첨가 PBS 용액 형태로 제공됩니다.
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- 1048-MSM14-P1ABX
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rC66, 1009 |
| Immunogen | Recombinant full-length human CEA protein (CD66e, CEACAM5, UniProt ID: P06731-1, antigen range: 1–702) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed at high levels in intestinal carcinomas and other tumors.
CEA belongs to the immunoglobulin supergene family and consists of one N domain and six constant-like domains (A1–A3, B1–B3).
Antibodies against CEA are useful for identifying the origin of metastatic adenocarcinomas and distinguishing pulmonary adenocarcinomas (60–70% CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell-cell adhesion molecule found in leukocytes, epithelia, and endothelia, and plays roles in tissue structure organization, angiogenesis, apoptosis, tumor suppression, metastasis, and immune response modulation.
Multiple transcript variants exist, though not all are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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