Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Recombinant Mouse Monoclonal Antibody (rC66, 1009)
CEA/CD66e 항원을 인식하는 Thermo Fisher Scientific의 재조합 마우스 모노클로날 항체(rC66, 1009). 인간 시료에 반응하며, 포르말린 고정 조직의 IHC(P) 분석에 적합. 고순도 Protein A/G 정제, 액상 형태, 4°C 보관.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rC66, 1009 |
| Immunogen | Recombinant full-length human CEA protein (CD66e, CEACAM5, UniProt ID: P06731-1, antigen range: 1–702) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues, heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors. It belongs to the carcinoembryonic antigen family within the immunoglobulin supergene family.
CEA consists of one N domain and six immunoglobulin constant-like domains (A1, A2, A3, B1, B2, B3). Antibodies against CEA help identify metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (typically CEA+) from pleural mesotheliomas (rarely CEA+).
CEA functions as a cell adhesion molecule found on leukocytes, epithelia, and endothelia, mediating homophilic and heterophilic interactions. It plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation. Multiple transcript variants exist, though not all full-length forms have been defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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