Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Recombinant Mouse Monoclonal Antibody (rC66, 1009)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• For Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors.
It belongs to the immunoglobulin supergene family, consisting of a single N domain and six constant-like domains (A1–A3, B1–B3).
CEA antibodies help identify the origin of metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely CEA+).
CEA functions as a cell adhesion molecule on leukocytes, epithelia, and endothelia, mediating homophilic and heterophilic binding.
It plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune response modulation.
Multiple transcript variants exist, though not all full-length forms have been defined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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