Thermo Fisher Scientific TIRAP Monoclonal Antibody (20D1055.1)
인간 TIRAP 단백질을 인식하는 마우스 단일클론 항체입니다. Western blot에 최적화되어 있으며, 비결합형 액상 형태로 제공됩니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific TIRAP Monoclonal Antibody (20D1055.1)
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 20D1055.1 |
| Immunogen | Human TIRAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_1087863 |
Product Specific Information
- Suggested positive control: Human spleen.
Target Information
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.
In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κB and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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