Thermo Fisher Scientific NALP10 Monoclonal Antibody (578502)

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

578502

Immunogen

E. coli-derived recombinant human NLRP10/Pynod/NALP10 Met386-Ile655 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NALP10,uniProtId:Q86W26-1,ncbiNodeId:9606,antigenRange:386-655,antigenLength:655,antigenImageFileName:MA5-24260_NALP10_Q86W26-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24260_NALP10_Q86W26-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606974

Product Specific Information

In direct ELISAs, no cross-reactivity with recombinant human (rh) NALP1 (aa 1-323), rhNALP1 (aa 1331-1429), rhNALP2 (aa 1-208), rhNALP3 (aa 3-223), rhNALP3 (aa 540-689), rhNALP5 (aa 469-635), rhNOD1 (aa 830-953), or rhNOD2 (aa 230-450) is observed.

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Target Information

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.