Thermo Fisher Scientific IL-34 Monoclonal Antibody (578416)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

2.5 µg per million cells

-

Neutralization (Neu)

0.01-0.05 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

578416

Immunogen

Mouse myeloma cell line NS0-derived recombinant human IL-34 Asn21-Pro242 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL-34,uniProtId:Q6ZMJ4-1,ncbiNodeId:9606,antigenRange:21-242,antigenLength:242,antigenImageFileName:MA5-24259_IL-34_Q6ZMJ4-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24259_IL-34_Q6ZMJ4-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607171

Product Specific Information

This antibody detects recombinant human IL-34 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse IL-34 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Endoxin level is <1.0 EU per 1 µg of the antibody by the LAL method.

Target Information

IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.