
Thermo Fisher Scientific CD16 Monoclonal Antibody (3G8)
인간 CD16 단백질을 인식하는 마우스 모노클로날 항체로, IHC(P) 및 유세포분석에 사용 가능. 비결합형 액상 형태로 제공되며, 단백질 A로 정제됨. 면역복합체 제거 및 세포매개 세포독성 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G8 |
| Immunogen | Recombinant protein of human CD16 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Spleen
- Cellular location: Secreted and membrane
Target Information
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and participates in immune complex clearance, cellular mediated cytotoxicity, and enhancement of viral infections.
The FCGR3A gene shares high similarity with FCGR3B on chromosome 1.
- FCGR3A: Expressed on NK cells as an integral membrane glycoprotein with a transmembrane anchor
- FCGR3B: Expressed on polymorphonuclear neutrophils (PMN) with a phosphatidylinositol (PI) linkage
Mutations in FCGR3A are associated with immunodeficiency 20, recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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