Thermo Fisher Scientific IL1B Monoclonal Antibody (1G8)
인간 IL-1β를 인식하는 마우스 단클론 항체로, Western blot 및 ELISA에 사용 가능. 비접합 액상 형태이며, 친화 크로마토그래피로 정제됨. 염화 PBS(pH 7.4)에 보존제 없이 보관하며, -20°C에서 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G8 |
| Immunogen | IL1B (AAH08678, 170 a.a. ~ 269 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DKIPVALGLK EKNLYLSCVL KDDKPTLQLE SVDPKNYPKK KMEKRFVFNK IEINNKLEFE SAQFPNWYIS TSQAENMPVF LGGTKGGQDI TDFTMQFVSS
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into an active 17 kDa form by caspase-1 following inflammasome activation. IL-1β plays a key role in innate immune defense by inducing other proinflammatory cytokines and initiating acute-phase responses. It signals through IL-1RI and IL-1RII receptors and can be regulated by IL-1 Receptor Antagonist (IL-1RA). Elevated IL-1β levels are associated with chronic inflammatory conditions, and IL-1β neutralizing antibodies have potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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