Thermo Fisher Scientific IL1B Polyclonal Antibody, MaxPab
IL1B 폴리클로날 항체로 인간 및 마우스 반응성. Western blot 및 in situ PLA에 최적화. 친화 크로마토그래피로 정제된 액상 형태. IL-1β 염증성 사이토카인 연구용으로 적합. 연구용 전용 제품.
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Thermo Fisher Scientific IL1B Polyclonal Antibody, MaxPab
Applications & Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| in situ PLA (PLA) | 1:1,200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IL1B (AAH08678.1, 1 a.a. ~ 269 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL GGTKGGQDIT DFTMQFVSS
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form and cleaved into an active 17 kDa protein via inflammasome activation. IL-1β lacks a classical secretion signal and is released through an alternative pathway alongside caspase-1. It signals through IL-1RI and IL-1RII receptors and its activity can be inhibited by IL-1RA. IL-1β plays a key role in innate immune defense and is associated with chronic inflammatory conditions. Neutralizing antibodies against IL-1β have potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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