Thermo Fisher Scientific IL1B Monoclonal Antibody (2E8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:

MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL GGTKGGQDIT DFTMQFVSS

Target Information

Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol. Activation of inflammasomes leads to cleavage of pro-IL-1β into the active 17 kDa protein via caspase-1. IL-1β lacks a signal peptide for the classical ER/Golgi pathway and is secreted through an alternate mechanism. It signals through IL-1RI and IL-1RII receptors and is regulated by IL-1 Receptor Antagonist (IL-1RA). IL-1β plays a key role in innate immunity and inflammation, with elevated levels linked to chronic inflammatory diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.