Thermo Fisher Scientific Periostin (POSTN) Monoclonal Antibody (POSTN, 3501)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 minutes.

Target Information

Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally identified as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for αVβ3 and αVβ5 integrins.
In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading, and attachment. It is mainly detected in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is upregulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF-β1). Periostin contains a typical signal sequence, a cysteine-rich domain, a fourfold repeated domain homologous to the insect protein fasciclin, and a C-terminal domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.