Thermo Fisher Scientific CDK8 Polyclonal Antibody
CDK8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 마우스에 반응하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 연구용 전용 제품입니다.
- 카탈로그번호
- PA5100715
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK8 (Accession P49336), corresponding to amino acid residues E14–C64 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850219 |
Product Specific Information
Antibody detects endogenous levels of total CDK8.
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the cyclin-dependent kinase (CDK) family, which regulates cell cycle progression. The prototype member, p34/Cdc2, and related Cdk2 function late in the cycle, while Cdk4 and Cdk6 are involved in G1 to S progression. Human Cdk8–Cyclin C complex may interact with RNA polymerase, influencing transcription mechanisms related to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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