Thermo Fisher Scientific CD63 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total CD63.

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a tetraspanin family glycoprotein found in late endosomes, lysosomes, and secretory vesicles. It is also present on the plasma membrane following cell activation and serves as a basophil activation marker. In mast cells, CD63 exposure does not require activation. CD63 interacts with integrins, influencing phagocytosis and cell migration, and participates in H/K-ATPase trafficking and ROMK1 channel regulation. It functions as a T-cell costimulation molecule and can be used as a prognostic marker in early-stage carcinomas. CD63 is expressed on activated platelets and translocated to the plasma membrane upon activation. It is also found in monocytes, macrophages, and weakly expressed in granulocytes, B, and T cells. CD63 is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunction of CD63 is associated with melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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