Thermo Fisher Scientific CD63 Polyclonal Antibody
CD63 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성. 고순도 친화 크로마토그래피 정제. -20°C 보관, 연구용 전용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD63 (Accession P08962), corresponding to amino acid residues D137–H187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850217 |
Product Specific Information
Antibody detects endogenous levels of total CD63.
Target Information
CD63 (LAMP-3, lysosome-associated membrane protein-3) is a tetraspanin family glycoprotein found in late endosomes, lysosomes, and secretory vesicles. It is also present on the plasma membrane following cell activation and serves as a basophil activation marker. In mast cells, CD63 exposure does not require activation. CD63 interacts with integrins, influencing phagocytosis and cell migration, and participates in H/K-ATPase trafficking and ROMK1 channel regulation. It functions as a T-cell costimulation molecule and can be used as a prognostic marker in early-stage carcinomas. CD63 is expressed on activated platelets and translocated to the plasma membrane upon activation. It is also found in monocytes, macrophages, and weakly expressed in granulocytes, B, and T cells. CD63 is identical to melanoma-associated antigen ME491 and platelet antigen PTLGP40. Dysfunction of CD63 is associated with melanoma and Hermansky-Pudlak Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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