Thermo Fisher Scientific RFWD3 Polyclonal Antibody
RFWD3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. DNA 손상 복구 관련 연구에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human RFWD3. Recombinant protein control fragment (Product #RP-108058) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2663710 |
Product Specific Information
Immunogen sequence:
NHTIPASSLHS MTNFISGLQR LHGMLEFLRP SSSNHSVGPM RTRRRVSASR RARAGGSQRT DSARLRAPLD AYFQVSRTQP DLPATTYDSE TRNPVSE
- Highest antigen sequence identity to orthologs: mouse 60%, rat 26%
Target Information
E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2, and RPA3 subunits) and RAD51 at stalled replication forks, promoting homologous recombination. Also mediates ubiquitination of p53/TP53 in the late response to DNA damage, acting as a positive regulator of p53/TP53 stability and the G1/S DNA damage checkpoint.
In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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