Thermo Fisher Scientific ATP2C2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ATP2C2 protein. Validated for ICC/IF applications. Antigen affinity purified and supplied as a liquid in PBS with glycerol. Suitable for research use in calcium transport and ATPase studies.
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Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATP2C2 (Recombinant protein control fragment, Product #RP-108060) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662202 |
Product Specific Information
Immunogen sequence:
WMAVKCSLKTE DQEDIYFMKG ALEEVIRYCT MYNNGGIPLP LTPQQRSFCL QEEKRM
Highest antigen sequence identity to orthologs:
- Mouse: 77%
- Rat: 77%
Target Information
ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting distinct physiological roles.
Unlike ATP2C1, ATP2C2 shows a more restricted expression pattern, a higher maximal turnover rate for Ca²⁺-ATPase activity, and a lower apparent affinity for cytosolic Ca²⁺ activation.
Overexpression of ATP2C2 in mammary tumors induces Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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