Thermo Fisher Scientific ATP2C2 Polyclonal Antibody

Applications and Tested Dilution

• Immunocytochemistry (ICC/IF): 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
WMAVKCSLKTE DQEDIYFMKG ALEEVIRYCT MYNNGGIPLP LTPQQRSFCL QEEKRM

Highest antigen sequence identity to orthologs:

• Mouse: 77%
• Rat: 77%

Target Information

ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting distinct physiological roles.
Unlike ATP2C1, ATP2C2 shows a more restricted expression pattern, a higher maximal turnover rate for Ca²⁺-ATPase activity, and a lower apparent affinity for cytosolic Ca²⁺ activation.
Overexpression of ATP2C2 in mammary tumors induces Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.