Thermo Fisher Scientific Melanophilin Polyclonal Antibody
Human Melanophilin 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Melanophilin. Recombinant protein control fragment (Product #RP-90841) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643870 |
Product Specific Information
Immunogen sequence:
ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS VGPLPQADPE VSDIESRIAA LRAAGLTVKP SGKPRRKSNL PIFL
Antigen sequence identity:
- Mouse: 41%
- Rat: 54%
Target Information
Slac2-a (synaptotagmin-like protein homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes.
It binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD) near the N-terminus.
Pigment and cytotoxic granule transport in melanocytes requires stable formation of this complex; mutations in these binding domains may cause albinism and/or severe immune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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