Thermo Fisher Scientific CD206 (MMR) Monoclonal Antibody (15-2)
CD206(MMR) 단일클론 항체로 인간 단백질에 반응하며, 주로 대식세포 및 수지상세포에서 발현되는 표적을 인식합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD206 (MMR) Monoclonal Antibody (15-2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-Dependent |
| Functional Assay | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 15-2 |
| Immunogen | Purified human mannose receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745540 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162–175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes.
Functional Application: Blocking.
Target Information
CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. It is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells, and sperm cells. CD206 plays a role in the innate and adaptive immune response and mediates recognition and uptake of macromolecules such as modified lipoproteins, AGEs, and amyloid β-protein.
It is implicated in atherosclerosis and Alzheimer’s disease, with isoform variations affecting endocytosis function. Type 3 isoform acts as a dominant negative regulator of receptor activity.
CD206 dysfunction is associated with diseases such as leprosy and Gaucher’s Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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