Thermo Fisher Scientific alpha-1 Antitrypsin Monoclonal Antibody (1AT11-210.1)

Applications

Tested Dilution

Publications

ELISA (ELISA)

1-10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1AT11-210.1

Immunogen

Purified human serum alpha-1 Antitrypsin. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:alpha-1 Antitrypsin,uniProtId:P01009-1,ncbiNodeId:9606,antigenRange:1-418,antigenLength:418,antigenImageFileName:MA1-10626_alpha-1_Antitrypsin_P01009-1_House_mouse.svg,antigenImageFileNamePDP:MA1-10626_alpha-1_Antitrypsin_P01009-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1070304

Product Specific Information

MA1-10626 detects alpha-1 Antitrypsin from human samples. MA1-10626 does not cross react with alpha-1-antichymotrysin.

MA1-10626 has been successfully used in ELISA applications.

The MA1-10626 immunogen is purified human serum alpha-1 Antitrypsin.

Target Information

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.