Thermo Fisher Scientific FAS Monoclonal Antibody (OTI1F2), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble 26 kDa form. Stimulation of FAS induces aggregation of intracellular FADD domains, formation of the death-inducing signaling complex (DISC), and activation of caspases, leading to apoptosis.
FAS can activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and participates in proliferative signaling in fibroblasts and T cells. Multiple alternatively spliced variants exist, some lacking transmembrane domains that negatively regulate apoptosis.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.