Thermo Fisher Scientific Human NELF Synthetic Peptide

Thermo Fisher Scientific Human NELF Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the center of human NELF.
PEP-1551 can be used as a blocking peptide with polyclonal antibody PA5-34508.

Target Information

NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in:

• Migration of LHRH neurons
• Outgrowth of olfactory axons
• Suppression of transcription elongation

NELF is expressed in the peripheral and central nervous system during embryonic development, and highly expressed in adult testis, kidney, and brain.
It couples NMDA receptor signaling to the nucleus. NELF knockdown impairs GnRH neuronal migration of NLT cells in vitro, and the gene encoding NELF has been linked to Idiopathic Hypogonadotropic Hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.