Thermo Fisher Scientific Human CCL4 (MIP-1 beta) Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the center of human CCL4.
PEP-1552 can be used as a blocking peptide with polyclonal antibody PA5-34509.

Target Information

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. It is produced by macrophages upon stimulation by bacterial endotoxins and recruits various inflammatory cells at sites of inflammation.
CCL4 is produced by lymphocytes, macrophages, and dendritic cells. Both CCL4 and the related protein CCL3 regulate the trafficking and activation of inflammatory cells in response to bacterial, viral, parasite, and fungal pathogens.
While both CCL4 and CCL3 affect monocytes similarly, CCL4 selectively attracts CD4+ lymphocytes, whereas CCL3 attracts CD8+ lymphocytes. Both are potent chemoattractants for B cells, eosinophils, and dendritic cells.
The processed form of CCL4 can down-modulate surface expression of the chemokine receptor CCR5, inhibiting CCR5-mediated HIV-1 entry in T cells. CCL4 binds with high affinity to CCR5 receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.