Thermo Fisher Scientific HMBS Monoclonal Antibody (OTI3E2), TrueMAB
HMBS 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화됨. Human 시료에 반응하며, HEK293T 세포에서 발현된 full-length HMBS 단백질로 면역화됨. Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도 유지. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E2 |
| Immunogen | Full-length human recombinant HMBS protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
PBGD (porphobilinogen deaminase), also known as hydroxymethylbilane synthase (HMBS), is a cytoplasmic enzyme involved in the heme biosynthesis pathway.
Deficiency of PBGD results in impaired pyrrole metabolism, leading to the inherited disorder acute intermittent porphyria (AIP).
AIP is characterized by acute neurological dysfunction, hypertension, tachycardia, peripheral neuropathy, abdominal pain, and elevated urinary aminolevulinic acid and porphobilinogen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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