Thermo Fisher Scientific CD275 (B7-H2) Monoclonal Antibody (599841)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 8–25 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.25 µg per million cells

Product Specifications

Product Specific Information

• In direct ELISAs, no cross-reactivity with recombinant human (rh) B7-H2, rhB7-H3, rhB7-H3b, rhPD-L2, recombinant mouse (rm) B7-1, rmB7-2, rmB7-H1, rmB7-H3, rmB7-H4, rmPD-L2, or recombinant rat B7-2 is observed.
• Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Target Information

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and peripheral tissue cells that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells, and B cells, and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T-cell proliferation and cytokine secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.