Thermo Fisher Scientific CRHBP Polyclonal Antibody
CRHBP 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 높은 순도(>95%)를 보유. 인간, 마우스, 랫트 시료에 반응.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein corresponding to amino acids 25–322 of human CRHBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719826 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus.
CRH is a 41 amino acid peptide derived from a 191 amino acid preprohormone and is produced in both the hypothalamus and peripheral tissues such as T lymphocytes and human placenta.
Glucocorticoids stimulate placental CRH synthesis and secretion, contrasting with their suppressive effect in the hypothalamus.
Human plasma contains a CRH-binding protein (CRH-BP or CRF-BP) that inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation during pregnancy.
The CRH gene maps to chromosome 8q13, and the CRF-BP gene maps to chromosome 5q11.2–q13.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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