Thermo Fisher Scientific COCH Polyclonal Antibody
Rabbit polyclonal antibody targeting human COCH protein. Validated for IHC(P) and ICC/IF applications. Affinity-purified with >95% purity. Supplied as liquid in PBS with 50% glycerol. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human COCH (amino acids 1–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2719824 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Cochlin is a secreted protein encoded by the COCH gene, which is highly expressed in the cochlea and constitutes about 70% of inner ear proteins. It exists in three glycosylated isoforms (p63s, p44s, p40) and contains an N-terminal LCCL domain and two von Willebrand factor A-like domains.
Mutations in COCH are associated with DFNA9, an autosomal dominant nonsyndromic auditory and vestibular dysfunction disorder. These mutations may lead to microfibrillar deposits containing Cochlin in the inner ear. Cochlin is also a target antigen in autoimmune sensorineural hearing loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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