Thermo Fisher Scientific FOXO4 Monoclonal Antibody (OTI2C5), TrueMAB
FOXO4 단백질을 인식하는 단일클론 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며, 고순도의 친화성 크로마토그래피로 정제되었습니다. 무보존제, 동결건조 형태로 -20°C 보관하며 연구용으로 사용됩니다.
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Thermo Fisher Scientific FOXO4 Monoclonal Antibody (OTI2C5), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Species Reactivity
- Human
- Mouse
- Rat
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 206–505 of human FOXO4 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene on the X chromosome. Also known as AFX1 or MLLT7, FOXO4 belongs to the O class of forkhead/winged helix transcription factors, along with FOXO1, FOXO3, and FOXO6.
FOXO4 is highly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1.
Phosphorylation by Akt induces FOXO4 binding to 14-3-3 proteins, leading to its nuclear export.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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