Thermo Fisher Scientific Doublecortin Polyclonal Antibody
Doublecortin 단백질을 표적하는 Thermo Fisher Scientific의 산양 유래 폴리클로날 항체로, 인간·생쥐·랫트 반응성. WB, IHC, ICC, ELISA에 적합하며, 신경세포 이동 연구용으로 사용. 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태로 제공.
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Thermo Fisher Scientific Doublecortin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:200 |
| Immunocytochemistry (ICC/IF) | 15 µg/mL |
| ELISA | 1:10,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a near C-terminal portion of human doublecortin conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.79 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human neuronal migration protein doublecortin. Blast analysis of the immunogen sequence shows 100% identity with rat.
Target Information
In the developing cortex, cortical neurons migrate over long distances to reach their final differentiation site. DCX is a cytoplasmic protein that regulates neuronal migration by organizing and stabilizing microtubules.
It contains two doublecortin domains that bind microtubules and interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase.
This interaction is essential for proper microtubule function in the developing cortex. Mutations in the DCX gene cause X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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