Thermo Fisher Scientific USP5 Monoclonal Antibody (OTI1F9), TrueMAB
USP5 단백질을 인식하는 Mouse monoclonal antibody. Western blot에 적합하며, HEK293T 세포에서 발현된 full-length 인간 USP5 단백질로 제작. 동결건조 형태로 제공되며, PBS와 trehalose로 안정화. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F9 |
| Immunogen | Full length human recombinant protein of human USP5 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers, showing preference for branched polymers.
It participates in disassembly of unanchored Lys-48-linked polyubiquitin and binds linear and Lys-63-linked polyubiquitin with lower affinity.
Knock-down of USP5 leads to accumulation of p53/TP53 and increased transcriptional activity due to competition between unanchored polyubiquitin and ubiquitinated p53/TP53 for proteasomal recognition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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