Thermo Fisher Scientific GRP94 Monoclonal Antibody (9G10), FITC

Applications and Tested Dilutions

Product Specifications

Additional Conjugate Formats

• APC
• PerCP
• Request custom conjugation

Product Specific Information

0.5 µg/mL of MA5-45097 was sufficient for detection of Grp94 in 20 µg of heat-shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-rat IgG:HRP as the secondary antibody.
Detects approximately 98 kDa. Does not detect human HSP90, Grp74, or GrpE from E. coli.

Target Information

GRP94 is an 803 amino acid protein belonging to the heat shock protein 90 family. It functions as a molecular chaperone involved in the processing and transport of secreted proteins.
GRP94 and its N-terminal fragment stimulate CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC).
It plays a central role in both innate and acquired immunity, dendritic cell maturation and chemotaxis, antibody production, cross-priming, and acts as a potential marker in breast cancer.
It serves as a peptide acceptor in the endoplasmic reticulum and assists peptide loading of MHC class I molecules.
Expression of GRP94 suppresses A23187-induced apoptosis and stabilizes calcium homeostasis.
GRP94 is expressed in melanoma, liver metastases of colon carcinoma cells, and human gastric carcinoma BGC-823 cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지