Thermo Fisher Scientific p35 Monoclonal Antibody (B.33.3)
p35 단백질을 인식하는 Rabbit monoclonal antibody로, WB, IHC(P), IP에 적합. 인간, 마우스, 랫트 반응성. 신경계 발달 및 알츠하이머 연구에 활용 가능. 고순도 액상 형태로 -20°C 보관.
- 카탈로그번호
- MA514834
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | - |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Cynomolgus monkey |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B.33.3 |
| Immunogen | Synthetic peptide from the carboxy terminus of human p35 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 146 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10978284 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The p35 protein is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), essential for central nervous system development. p35 is cleaved by calpain into p25, causing relocalization from the cell periphery to nuclear regions. The p25 form prolongs CDK5 activation and alters its localization. In Alzheimer’s disease, p25 accumulates in brain neurons, correlating with increased CDK5 activity and abnormal phosphorylation of tau protein, contributing to disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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