Thermo Fisher Scientific SCD Polyclonal Antibody
Thermo Fisher Scientific의 SCD Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, Western blot과 면역세포화학(ICC/IF)에 적합합니다. Rabbit IgG 폴리클로날 항체로, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding R347 of human SCD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 16 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980271 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction.
Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only two SCD isoforms, SCD1 and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all four mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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