Thermo Fisher Scientific Metadherin Recombinant Rabbit Monoclonal Antibody (4V0R6)
Metadherin 단백질을 표적하는 재조합 토끼 단클론 항체로, IHC(P) 및 ELISA에 적합합니다. HEK293 세포에서 발현되며 Protein A로 정제되었습니다. 인간, 마우스, 랫트 반응성을 가지며, -20°C에서 안정적으로 보관 가능합니다.
- 카탈로그번호
- MA555287
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4V0R6 |
| Immunogen | A synthetic peptide corresponding to amino acids 308–407 of human LYRIC/AEG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.12 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
SPASAGKRKT EPSAWSQDTG DANTNGKDWG RSWSDRSIFS GIGSTAEPVS QSTTSDYQWD VSRNQPYIDD EWSGLNGLSS ADPNSDWNAP AEEWGNWVDE
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein localized with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is recruited during tight junction maturation rather than serving as a structural component. Metadherin is overexpressed in breast cancer tissues and xenografts, with low expression in normal breast tissue. It binds to lung vasculature via its C-terminal extracellular domain, and blocking this domain has been reported to inhibit breast cancer metastasis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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