Thermo Fisher Scientific Ki-67 (Proliferating Cell Marker) Recombinant Mouse Monoclonal Antibody (rMKI67/4948)
세포 증식 마커 Ki-67에 특이적인 재조합 마우스 단클론 항체. Western Blot 및 ELISA에 사용 가능. 인간 시료 반응성, 핵 내 발현 단백질 검출용. 단백질 A로 정제된 액상 항체로 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| ELISA | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rMKI67/4948 |
| Immunogen | Recombinant fragment (around aa2200–2500) of human MKI67 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Any actively proliferating cells such as human skin, tonsil, or lymph node.
- Cellular Location: Nucleus.
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle, particularly in late G1, S, G2, and M phases. It contains a forkhead-associated (FHA) domain that mediates association with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus.
The protein shows cell cycle-dependent localization: perinucleolar in G1, nuclear matrix in G2, and chromosomal during M phase.
Ki-67 is widely used as a marker of proliferation because it is absent in G0 cells and increases from G1 through mitosis. It helps determine the growth fraction in neoplasms, and its index correlates with tumor grade.
Commonly used as a neuronal marker of cell cycling and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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