Thermo Fisher Scientific FMO1 Polyclonal Antibody
Thermo Fisher Scientific의 FMO1 Polyclonal Antibody는 인간 FMO1 단백질을 인식하는 고순도 항체로, WB, IHC, ICC/IF 등에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 안정적인 장기 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human FMO1 (UniProt ID: Q01740-1, Antigen Range: 1–532) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720788 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans, resulting in a small subpopulation with reduced TMA N-oxidation capacity (fish odor syndrome, trimethylaminuria).
Three forms of the enzyme are encoded by genes clustered in the 1q23–q25 region:
- FMO1: Found in fetal liver
- FMO2: Found in adult liver
- FMO3: Associated with TMA metabolism
Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyze the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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