Thermo Fisher Scientific PYY Monoclonal Antibody (4)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

4

Immunogen

Synthetic N-terminal fragment of human PYY(3-36) coupled to carrier. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PYY,uniProtId:P10082-1,ncbiNodeId:9606,antigenRange:3-36,antigenLength:97,antigenImageFileName:ABS_051-04-02_PYY_P10082-1_House_mouse.svg,antigenImageFileNamePDP:ABS_051-04-02_PYY_P10082-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.08 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536229

Product Specific Information

Specificity: ABS 051-04-02 binds human PYY (3-36). This antibody does not cross-react with PYY (1-36) from mouse, rat, dog or pig samples.

Reactivity: ABS 051-04-02 binds free PYY (3-36) in solution. The recommended ELISA dilution is 1:20,000 for PYY (3-36) coated directly at 1 µg/mL. ABS 051-04-02 can be used as a capture antibody in a sandwich ELISA using biotinylated detection antibody ABS 029-01-02.

NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL

Target Information

Peptide tyrosine-tyrosine amide (3-36), or PYY (3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY (3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY (3-36) is additive to that of the co-secreted gut hormone GLP-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.