Thermo Fisher Scientific Thomsen-Friedenreich Antigen/CD176 (Pan Carcinoma Marker) Monoclonal Antibody (A63-C/A9)
Thomsen-Friedenreich 항원(CD176)을 인식하는 단클론 항체로, 다양한 암 조직에서 발현되는 Pan Carcinoma Marker입니다. IHC, ICC/IF 등 다양한 응용에 적합하며, Human, Mouse, Rat에 반응합니다. 단백질은 PBS 용액에 보존되며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A63-C/A9 |
| Immunogen | Neuraminidase-treated human red blood cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Thomsen-Friedenreich antigen acts as an oncofetal antigen, showing low expression in normal adult tissues but increasing to fetal levels in hyperplasia or malignancy. It is considered a pan-carcinoma marker. This gene belongs to the mucin family and encodes a membrane-bound, glycosylated phosphoprotein anchored to the apical surface of many epithelia. The degree of glycosylation varies by cell type. It includes a 20 amino acid variable number tandem repeat (VNTR) domain, with repeats ranging from 20 to 120 among individuals. The protein provides protection by binding to pathogens and functions in cell signaling. Overexpression, altered localization, and glycosylation changes are associated with carcinomas. Multiple alternatively spliced transcript variants exist, though not all full-length sequences are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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