Thermo Fisher Scientific Human IRE1 alpha Synthetic Peptide
Human IRE1 alpha 단백질의 중심부 15개 아미노산 서열 기반 합성 펩타이드. Polyclonal antibody PA5-20191의 blocking peptide로 사용 가능. 인간 IRE1 신호 전달 연구용. 액상 형태로 제공되며 PBS buffer에 보관.
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Thermo Fisher Scientific Human IRE1 alpha Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human IRE1p.
PEP-0321 can be used as a blocking peptide with polyclonal antibody PA5-20191.
Target Information
ERN1 (serine/threonine kinase) or endoplasmic reticulum to nucleus signaling 1 is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activity and plays a key role in endoplasmic reticulum-based stress signaling.
IRE1 acts as a sensor of unfolded proteins in the ER, initiating the unfolded protein response by splicing XBP1 mRNA into a potent transcriptional activator.
Null mutants are viable, but IRE1 is essential under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p can lead to apoptosis under such stress conditions.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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